| J | Fecha | Local | Res. | Visitante | |
| 1 | 18/9/2005 | Cultu Leonesa B | 1 - 0 | Leon FC | |
| 2 | 25/9/2005 | Atco Astorga | 1 - 0 | Cultu Leonesa B | |
| 3 | 2/10/2005 | Cultu Leonesa B | 1 - 0 | AD Castilla Par | |
| 4 | 9/10/2005 | AD MIR PRESAN | 1 - 2 | Cultu Leonesa B | |
| 5 | 16/10/2005 | Cultu Leonesa B | 3 - 2 | CD Bejar In | |
| 6 | 23/10/2005 | Union Delicas | 2 - 0 | Cultu Leonesa B | |
| 7 | 6/11/2005 | Cultu Leonesa B | 1 - 1 | Sanabria FC | |
| 8 | 13/11/2005 | C La Rubia | 1 - 0 | Cultu Leonesa B | |
| 9 | 20/11/2005 | Cultu Leonesa B | 1 - 0 | CF Pizarrales | |
| 10 | 27/11/2005 | CD Bosco | 2 - 1 | Cultu Leonesa B | |
| 11 | 4/12/2005 | Cultu Leonesa B | 2 - 1 | CD Jher Iscar | |
| 12 | 11/12/2005 | EF Navega | 1 - 0 | Cultu Leonesa B | |
| 13 | 18/12/2005 | Cultu Leonesa B | 1 - 1 | UDC Sur | |
| 14 | 15/1/2006 | Atco Bembibre | 2 - 0 | Cultu Leonesa B | |
| 15 | 22/1/2006 | Cultu Leonesa B | 1 - 0 | Zamora CF | |
| 16 | 29/1/2006 | Leon FC | 2 - 0 | Cultu Leonesa B | |
| 17 | 5/2/2006 | Cultu Leonesa B | 1 - 1 | Atco Astorga | |
| 18 | 12/2/2006 | AD Castilla Par | 1 - 0 | Cultu Leonesa B | |
| 19 | 19/2/2006 | Cultu Leonesa B | 2 - 0 | AD MIR PRESAN | |
| 20 | 26/2/2006 | CD Bejar In | 0 - 4 | Cultu Leonesa B | |
| 21 | 5/3/2006 | Cultu Leonesa B | 2 - 1 | Union Delicas | |
| 22 | 12/3/2006 | Sanabria FC | 2 - 1 | Cultu Leonesa B | |
| 23 | 26/3/2006 | Cultu Leonesa B | 3 - 0 | C La Rubia | |
| 24 | 2/4/2006 | CF Pizarrales | 2 - 0 | Cultu Leonesa B | |
| 25 | 9/4/2006 | Cultu Leonesa B | 3 - 2 | CD Bosco | |
| 26 | 16/4/2006 | CD Jher Iscar | - | Cultu Leonesa B | |
| 27 | 23/4/2006 | Cultu Leonesa B | 2 - 1 | EF Navega | |
| 28 | 7/5/2006 | UDC Sur | 4 - 2 | Cultu Leonesa B | |
| 29 | 14/5/2006 | Cultu Leonesa B | 0 - 2 | Atco Bembibre | |
| 30 | 21/5/2006 | Zamora CF | 2 - 1 | Cultu Leonesa B |
| Creado el 22-mayo-2006 cón LeaguePad |